Genetic polymorphisms as determinants for disease-preventive effects of vitamin E.
Authors:
Zingg, Jean-Marc Azzi, Angelo Meydani, Mohsen USDA, ARS
Source:
Nutrition reviews. 2008 July, v. 66, no. 7, p. 406-414.
NALT Subjects:
humans genetic polymorphism vitamin E nutrient uptake disease prevention diet therapy vitamin supplements haptoglobins free radicals ascorbic acid literature reviews
Issue Date:
Jul-2008
Abstract:
Polymorphisms in genes involved in vitamin E uptake, distribution, metabolism, and molecular action may be important determinants for the protective effects of vitamin E supplementation. The haptoglobin 2-2 polymorphism is associated with increased production of oxygen free radicals and reduces levels of vitamin E and C; the consequent elevated risk for cardiovascular disease can be prevented by vitamin E supplementation.
